Nocturnal hypoglycaemia poses a particular challenge because the sleeping patient is not in a position to intervene and many episodes are asymptomatic. Repeated exposure to nocturnal hypoglycaemia can blunt counterregulatory mechanisms, with potentially serious clinical consequences.2
Intensive glucose-lowering therapy may not achieve its purpose – avoidance of mortality and morbidity from diabetes complications – unless hypoglycaemia risk can be managed. Strategies to minimize hypoglycaemia can help patients safely achieve glycaemic control and thus prevent or delay complications.
- Glucose concentrations of less than 3.0 mmol/L (54 mg/dL) should be reported in clinical trials: a joint position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Published in both Diabetes Care 2017 Jan; 40(1): 155-157 and Diabetologia 2017;6-:3-6.
- Cryer PE. Glycemic goals in diabetes: trade-off between glycemic control and iatrogenic hypoglycemia. Diabetes 2014;63:2188.